Immunomodulacja: leczenie żywieniem – cz. II

Stage III: Active modulation of the immune system

In Stage III the emphasis is to actively interact with the immune system attempting to modulate its function towards a desired goal. Examples would include:

1. Reversing the Th2 bias and restoring Th1 response by enabling efficient antigen presentation: A Th1 (pro-inflammatory) response is important for protection against microbial infections. Th1 component of the immune system is boosted by stimulating the immune system with probiotic bacteria or PAMP expressing moieties (e.g. yeast beta-glucans). Probiotics (Enterococcus faceum, Lactobacilli sp., Bifidobacteria sp. etc) in diet have been shown to enhance the immune status in dogs (Benyacoub et al., 1158-62). Milk bioactives from bovine colostrum have been show to have immune enhancing effects in both human and murine studies and they are an interesting immunomodulating ingredient. Colostrum (and whey protein which has very similar composition) contains immunoglobulins, cytokines, lactoferrin, and lactoperoxidase, each of them can influence the immune system (Artym et al., 9-15). Mice fed with milk bioactives produced significantly higher serum and intestinal antibodies to several antigens (influenza virus, diphtheria and tetanus toxin, poliomyelitis vaccine, ovalbumin and cholera toxin sub-unit) (Low et al., 393-401). In another study, mice fed with milk bioactives had enhanced resistance to pneumococcal infection (Bounous et al., 343-49; Bounous, Batist, and Gold, 154-61). In in vitro studies conducted with human monocytes, Biswas et al (Biswas et al., 447-54) report that co-culture with bovine [...]

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