Immunomodulacja: leczenie żywieniem – cz. I

Stress

Stress, both physical and mental, has a significant negative impact on the immune system, irrespective of age. Both major and minor stressful events have been shown to have a profound influence on immune responses in both animal and human studies. One of the hall marks of chronic stress is the general increase in levels of oxidative stress, and oxidative stress gradually erodes immune plasticity.

Research in this area has spawned a new discipline called ‘psychoneuroimmunology’ – study of the interaction between the psychological process and the nervous system and the immune system. Using vaccine responses as a indicator of immune status (Kiecolt-Glaser et al., 83-107; Kiecolt-Glaser et al., 680-85; Kiecolt-Glaser et al., 3043-47; Morag et al., 389-95; Vedhara et al., 627-31; Jabaaij et al., 129-37), researchers have demonstrated that among medical students taking exams, the level of stress lowered the response to vaccine (virus-specific antibody and T cell responses to hepatitis B vaccine were lower), while the degree of social support increased vaccine response (Kiecolt-Glaser et al., 680-85).

Another good example of chronic stress is the stress associated with care giving for a spouse with Alzheimer’s Disease (AD), which was associated with a poorer response to an influenza virus vaccine when compared to well matched control subjects (Kiecolt-Glaser et al., 3043-47). Vaccine responses demonstrate clinically relevant alterations in an immunological response to challenge under well [...]

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