Asparaginaza i protokół MOPP w leczeniu chłoniaków u psów

Toxicoses

Seventy-six percent (38/50) of the dogs had at least 1 episode of hematologic toxicosis. Thirty-eight percent (19/50) experienced at least 1 episode of neutropenia and 60% (30/50) experienced at least 1 episode of thrombo-cytopenia. However, the majority of the hematologic toxicoses were mild and clinically insignificant. Of the 29 episodes of neutropenia, 38% (11/29) were grade III (500-999/mL) or IV (o 500/mL), and of the 110 episodes of thrombocytopenia 18% (20/110) were grade III (25,000-49,000/mL) or IV (o25,000/mL). Three dogs in the study were hospitalized because of fever and signsconsistent with sepsis.

Two of the dogs had grade III neutropenia and 1 dog had grade IV neutropenia. All dogs recovered with supportive care consisting of IV fluids and antibiotics. Two dogs were hospitalized due to ane-mia (hematocrits 16.3 and 20.3%) necessitating blood transfusion. One of these dogs that had received 7 cycles of MOPP and was in clinical remission had concurrent grade IV thrombocytopenia and subsequently died. A bone marrow evaluation performed 2 days before death did not detect lymphoma. This dog was the only one to die because of adverse effects of chemotherapy.

Gastrointestinal toxicosis was a common finding in this study, with 78% (39/50) of the dogs having at least 1 episode. The majority of the episodes of gastrointestinal toxicosis were mild and self-limiting. Of the 47 episodes of vomiting only [...]

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