Asparaginaza i protokół MOPP w leczeniu chłoniaków u psów

Assessment of response

Complete response (CR) was elimination of all detectable disease. CR was then subdivided into complete response-1 (CR-1) and complete response-2 (CR-2). CR-1 refers to dogs that achieved a CR and maintained it throughout the entire 28 day MOPP cycle. CR-2 refers to dogs that achieved a CR, relapsed between days 7 and 28, and subsequently responded to the next MOPP cycle (16).

Par-tial response (PR) was considered a 450% reduction but o100% reduction in measurable disease for 1 chemotherapy cycle, stable disease (SD) was considered o50% reduction or no change in size of all measurable disease for 1 chemotherapy cycle and progressive disease (PD) was considered a 425% increase in measurable disease or appearance of new neoplastic lesions. In addition, a dog was also considered to have PD if hypercalcemia recurred despite no change in gross disease in a dog that was previously in CR/PR/SD with normal plasma ionized calcium concentration.

Statistical analysis

Response rate was defined as the number of dogs that achieved CR or PR compared with the total number of dogs treated. Overall survival time (OST) was defined as the time from initiation of treat-ment until cancer-related death. Progression-free survival (PFS) was defined as the time from initiation of treatment until evidence of PD (either recurrence of gross disease or return of [...]

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