Niedokrwistości ze szczególnym uwzględnieniem anemii immunohemolitycznych – cz. II

Immunosuppressive therapy

Many immunosuppressive drugs were used in every animal with IMHA, although the product, formulation and dose varied between reports. Across studies, the dose ranges of the 5 most widely used drug were: prednisone/prednisolone 1-8 mg/kg/day; dexamethasone 0.2-1 mg/kg/day; azathioprine 1-2.7 mg/kg/day; cyclosporine 3-8 mg/kg/day; cyclophosphamide 1.1-3.3 mg/kg/day or 50 mg/m²/day for 4 days or an initial dose of 200 mg/m² followed by 50 mg/m²/day for 3 days.

Glucocorticoids

Glucocorticoids administered at immunosuppressive dosages either as prednisone or dexamethasone are the primary therapy for IMHA. The benefit of prednisone versus dexamethasone in the treatment of this disease is unknown, and the choice of drug seems to depend on whether the dog can tolerate the oral administration of medications and the preference of the clinician. Furthermore, the optimal dosage of either drug for the treatment of canine IMHA has not been determined; however, most clinicians use 0.5-1.0 mg/kg of dexamethasone once or 1-2 mg/kg of prednisone twice a day. This dosage is similar to the glucocorticoid dose used for other immune-mediated disorders in dogs.

Cyclophosphamide

Cyclophosphamide does not improve and may adversely affect the initial treatment of IMHA in dogs and cannot be recommended (3, 12, 13).

Azathioprine

Azathioprine is carcinogenic [...]

Ten materiał dostępny jest tylko dla użytkowników
którzy są subskrybentami naszego portalu.

Wybierz pakiet subskrypcji dla siebie
i ciesz się dostępem do bazy merytorycznej wiedzy!

Wybierz subskrypcję

Masz aktywną subskrypcję?

Zaloguj się

Nie masz jeszcze konta w serwisie? Dołącz do nas