Cytologia nowotworów mezenchymalnych

Specific tumors 

Often the cytologic interpretation of malignant mesenchymal neoplasia is simply ‘sarcoma’, but occasionally cell morphology is distinctive enough to suggest a potential specific tumor type. Histopathology is always recommended to determine the specific type of sarcoma, however, because some have considerably better prognoses than do others. Described below are typical cytologic features of some of the more distinctive mesenchyal tumors:

1. Lipoma and liposarcoma. Aspirates from lipomas (benign) and liposarcomas (malignant) frequently appear grossly greasy on the slide. Because fat is dissolved in the alcohol fixative of cytology.
   stains, aspirate samples from lipomas may be almost acellular following staining. In samples from lipomas, normal adipocytes occur in low numbers, usually in aggregates of very large cells with small, inapparent nuclei that are compressed to one side of the cell (Fig. 1). The cytoplasm of these cells is distended with clear lipid globules. Remember that subcutaneous fat has an identical cytologic appearance, so sampling error should always be considered. Aspirates from liposarcomas have much higher cellularity (Fig. 2). Cells often have spindled pale cytoplasm containing variably-sized lipid globules, but less differentiated tumors may contain little lipid. Criteria of malignancy may be moderate or marked. There may be round lipid clearings visible [...]

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