Przegląd chorób o podłożu genetycznym przebiegających z objawami neurologicznymi

Polyneuropathy in alaskan malamute

In the course of polyneuropathy, functional disturbances in the peripheral nervous system are observed due to nerve degeneration. As a result, the lack of neural stimulation results in slow atrophy of the muscles. The causative mutation in alaskan malamutes is different from the one described in greyhound dogs.

The clinical symptoms are seen in the first two years of life, most commonly between 12 and 18 month (8), and include progressive muscle atrophy that predominantly affects arm and thigh muscles (8), exercise intolerance; reflex disturbances and four-limb ataxia. An animal may fall down and its walking may appear atypical. If paralysis affects the larynx, vocalization changes, problems with swallowing and vomiting may be seen. Megaoesophagus may also develop (8). The general condition of a dog is not impacted by the disease.

There is a variety of other neurological disorders that present with similar clinical symptoms and therefore the disease is often undiagnosed or misdiagnosed.  Breed: alaskan malamute. Pattern of inheritance: autosomal recessive.

GM1-gangliosidosis

GM1-gangliosidosis belongs to the group of lysosomal storage diseases and results in neurological abnormalities. The disorder is asymptomatic in newborn puppies and after 3 to 8 weeks the first symptoms are seen, namely loss of weight gains, clumsy walking, uncoordinated head movements and nystagmus, The signs become more [...]

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