Asparaginaza i protokół MOPP w leczeniu chłoniaków u psów
Two prognostic factors, the presence of hypercalcemia and the presence of a cranial mediastinal mass, have been associated with the T-cell phenotype and with a poor prognosis, with survival times of 3.7 and 3 months, respectively (2-4, 7, 13-15, 23, 24). In the current study, the presence of a cranial mediastinal mass was not associated with a decrease in either PFS or OST.
The median PFS of dogs with a cranial mediastinal mass was not reached at 260 days and the median OST was 387 days. Further-more, the median PFS and median OST for dogs with hypercalcemia in this study were 189 and 270 days re-spectively and were not significantly different from the median PFS and median OST of dogs without hypercal-cemia. These results suggest that within our population of dogs with T-cell lymphoma, the presence of a cranial mediastinal mass, hypercalcemia, or both does not result in shorter PFS or OST when MOPP chemotherapy is used.
Along with the T-cell phenotype, substage has been shown to be a strong negative prognostic factor for dogs with lymphoma(2, 3, 7, 12, 24). Median remission times and survival times for dogs presenting with substage B lymphoma range from 37 to 165 days 44 to 137 days, respectively (2, 12, 26). However, in the current study substage was not predictive of PFS or OST. The median PFS and OST for dogs presenting substage B were [...]
którzy są subskrybentami naszego portalu.
i ciesz się dostępem do bazy merytorycznej wiedzy!
POSTĘPOWANIA
w weterynarii
